In 1869, Swiss scientist Friedrich Miescher isolated a mysterious substance from cell nuclei—an overlooked finding that would later reshape biology and our understanding of life itself. A ...

Thymine modified polymer for delivering DNA into cells. A thymine modified compound, poly (ethylene glycol) (PEG), is bound to DNA through an annealing process, then delivered by intramuscular ...

Single-molecule imaging has revolutionised our understanding of how proteins engage with DNA by allowing direct visualisation of individual molecular events. Instead of averaging over large ensembles, ...

When environmental stress harms DNA, it can set off a cascade of failures linked to heart conditions, neurodegeneration, and chronic inflammation. A new chemical tool developed at UC Riverside ...

Researchers have demonstrated a novel AI model that can predict which DNA molecules bind with other DNA molecules. A more ...

As genome editing therapies move through clinical trials to regulatory approval, scientists continue the quest for the holy ...

Scientists developed a charge-free polymer-DNA complex that boosts cellular DNA uptake 14-fold in mice, avoiding the harmful inflammation caused by current methods. Many existing options rely on ...

Schematic showing a single DNA duplex bridging two gold electrodes (yellow) patterned on a silicon nitride substrate (green). The setup allows measurement of electrical conductance as metal ions bind ...

Getting DNA into a living cell sounds simple, until you remember the cell's outer membrane acts like a guarded wall. DNA strands carry a negative charge, and they do not cross that wall easily. So for ...

In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

For more than three decades, DNA has been considered the gold standard of forensic science. It has transformed criminal ...