一个窒息复苏后的早产儿，医嘱开具肝肾功、电解质、心肌酶、动脉血气等抽血项目，如果按常规的话，需要抽一次动脉血，一次静脉血。 护士为减少连续穿刺给患儿带来的不良刺激，决定经桡动脉穿刺抽血。但穿刺过程并不顺利，来回探了几次才见回血，抽够 ...

Methods: To achieve these objectives, we included 14 healthy participants aged 23-39 years in the study, and we induced several stable plateaus of arterial oxygen saturation (SaO2) ranging from ...

1 Department of Epidemiology & Biostatistics, Erasmus Medical Centre, the Netherlands 2 Department of Neurology, Erasmus Medical Centre, the Netherlands 3 Department of Radiology, University Hospital ...

Cytokinetics has revealed the results from a phase 3 trial of its hypertrophic cardiomyopathy (HCM) drug aficamten that it hopes will allow it to compete with Bristol-Myers Squibb’s first-to-market ...

Introduction & Objectives Idiopathic arterial pulmonary hypertension (IPAH) is a chronic, progressive respiratory disease, characterised by elevated pulmonary artery pressure. The disease carries ...

Persistent pulmonary hypertension of the newborn (PPHN) is the most common neonatal form and mostly reversible after a few days with improvement of the underlying pulmonary condition. When pulmonary ...

Background Community-acquired pneumonia (CAP) is a leading cause of childhood hospitalisation. Limited data exist on factors predicting severe disease with no paediatric-specific predictive tools.

肥厚型心肌病（HCM）是临床上最常见的遗传性心脏病，其病理特征在于心肌肌节（sarcomere）蛋白质基因突变导致的心肌过度收缩与舒张功能障碍。约有三分之二的患者表现为梗阻性肥厚型心肌病（oHCM），即由于室间隔不对称性肥厚，导致左心室流出道（LVOT）在 ...

The last 3 decades have seen a revolution in our understanding of the physiology and pathophysiology of iron metabolism in the cardiovascular system. In this review, we highlight the key role of iron ...

Cardiac myosin inhibitors were recently developed to address the underlying pathophysiology of hypertrophic cardiomyopathy and to improve symptoms and quality of life. In this review, we evaluated the ...

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Within the cardiac sarcomere, myosin in thick filaments interacts with actin in thin filaments to promote contraction. The chemomechanical cycle represents the steps leading to myosin powerstrokes ...