The last 3 decades have seen a revolution in our understanding of the physiology and pathophysiology of iron metabolism in the cardiovascular system. In this review, we highlight the key role of iron ...

Methods: To achieve these objectives, we included 14 healthy participants aged 23-39 years in the study, and we induced several stable plateaus of arterial oxygen saturation (SaO2) ranging from ...

Cardiac myosin inhibitors were recently developed to address the underlying pathophysiology of hypertrophic cardiomyopathy and to improve symptoms and quality of life. In this review, we evaluated the ...

Within the cardiac sarcomere, myosin in thick filaments interacts with actin in thin filaments to promote contraction. The chemomechanical cycle represents the steps leading to myosin powerstrokes ...

肥厚型心肌病（HCM）是一种原发性心肌病，主要特征是在没有其他心脏、系统性或代谢性疾病的情况下出现左心室肥大，可在患者人生中任意阶段发病[1,2]。与成人相比，18 岁以下儿童及青少年 HCM 预后更差、危及生命的心律失常发生风险更大，心脏性猝死的风险 ...

肥厚型心肌病（HCM）是临床上最常见的遗传性心脏病，其病理特征在于心肌肌节（sarcomere）蛋白质基因突变导致的心肌过度收缩与舒张功能障碍。约有三分之二的患者表现为梗阻性肥厚型心肌病（oHCM），即由于室间隔不对称性肥厚，导致左心室流出道（LVOT）在 ...

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The MarketWatch News Department was not involved in the creation of this content. Results of dose-ranging study suggest potential for best-in-class clinical profile across efficacy, safety and ease of ...